产品名称
NOXA1 Rabbit Polyclonal Antibody
蛋白名称
NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q86UR1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86UR1/entry
Mouse Swissprot No.
Q8CJ00
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CJ00
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941A7E3N7
免疫原
Synthesized peptide derived from part region of human protein
特异性
NOXA1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
组织表达
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
细胞定位
Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
功能
developmental stage:Expressed in fetal kidney.,domain:The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.,domain:The TPR repeats mediate interaction with RAC1.,function:Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.,PTM:Interaction with YWHAZ depends on phosphorylation by PKA.,similarity:Belongs to the NCF2/NOXA1 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 4 TPR repeats.,subcellular location:Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1.,tissue specificity:Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
