BD-PN3026

TAP1 Rabbit Polyclonal Antibody

常规抗体

TAP1 ABCB2 PSF1 RING4 Y3

Antigen peptide transporter 1 (APT1) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

6890

Q03518

https://www.uniprot.org/uniprotkb/Q03518/entry

P21958

http://www.uniprot.org/uniprot/P21958

P36370

http://www.uniprot.org/uniprot/O54941P36370

Synthesized peptide derived from part region of human protein

TAP1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

88kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014],

Higly expressed in professional APCs monocytes and dendritic cells as well as in lymphocyte subsets T cells, B cells and NK cells.

Endoplasmic reticulum membrane ; Multi-pass membrane protein . The transmembrane segments seem to form a pore in the membrane.

ABC transporters;Antigen processing and presentation;Primary immunodeficiency;

caution:It is uncertain whether Met-1 or Met-61 is the initiator.,disease:Defects in TAP1 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also called HLA class I deficiency. BLS1 is a class I antigen deficiency that is not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.,domain:The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.,function:Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.,induction:By interferon gamma.,online information:TAP1 mutation db,polymorphism:There are five common alleles; TAP1*0101 (PSF1A), TAP1*0201 (PSF1B), TAP1*0301 (PSF1C), TAP1*0104 and TAP1*x. The sequence of TAP1*0101 is shown here.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. MHC peptide exporter (TC 3.A.1.209) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subcellular location:The transmembrane segments seem to form a pore in the membrane.,subunit:Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.