产品名称
DERL2 Rabbit Polyclonal Antibody
基因名称
DERL2 DER2 FLANA CGI-101 SBBI53
蛋白名称
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9GZP9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9GZP9/entry
Mouse Swissprot No.
Q8BNI4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BNI4
免疫原
Synthesized peptide derived from part region of human protein
特异性
DERL2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
derlin 2(DERL2) Homo sapiens Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008],
组织表达
Ubiquitous. Overexpressed in various hepatocarcinomas.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
function:Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.,induction:Up-regulated in response to ER stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).,similarity:Belongs to the derlin family.,subunit:Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1. Interacts with SELS, VCP and EDEM1. Mediates association between VCP and EDEM1, as well as that between VCP and the degradation substrate. Interacts with the SEL1L/SYVN1 and VCP/SELS protein complexes.,tissue specificity:Ubiquitous. Overexpressed in various hepatocarcinomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
