BD-PN3021

DERL1 Rabbit Polyclonal Antibody

常规抗体

DERL1 DER1 UNQ243/PRO276

Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

79139

Q9BUN8

https://www.uniprot.org/uniprotkb/Q9BUN8/entry

Q99J56

http://www.uniprot.org/uniprot/Q99J56

Synthesized peptide derived from part region of human protein

DERL1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

27kD

-20°C/1 year

Polyclonal, Rabbit,IgG

derlin 1(DERL1) Homo sapiens The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012],

Ubiquitous.

Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Amyotrophic lateral sclerosis (ALS);

function:Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.,induction:Up-regulated in response to ER stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).,similarity:Belongs to the derlin family.,subunit:Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts with AMFR, SELS/VIMP, SEL1L, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-SELS protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with the cytomegalovirus US11 protein. Interacts with NGLY1. Does not bind to EDEM1.,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.