产品名称
CO8G Rabbit Polyclonal Antibody
蛋白名称
Complement component C8 gamma chain
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P07360
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07360/entry
Mouse Swissprot No.
Q8VCG4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCG4
免疫原
Synthesized peptide derived from part region of human protein
特异性
CO8G Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011],
信号通路
Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;
功能
function:C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.,similarity:Belongs to the calycin superfamily. Lipocalin family.,subunit:C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
