产品名称
DLL4 Rabbit Polyclonal Antibody
基因名称
DLL4 UNQ1895/PRO4341
蛋白名称
Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NR61
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NR61/entry
Mouse Swissprot No.
Q9JI71
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JI71
免疫原
Synthesized peptide derived from part region of human protein
特异性
DLL4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008],
组织表达
Expressed in vascular endothelium.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
domain:The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.,function:Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4.,PTM:Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.,similarity:Contains 1 DSL domain.,similarity:Contains 8 EGF-like domains.,subunit:Binds to Notch-1 and Notch-4.,tissue specificity:Expressed in vascular endothelium.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
