产品名称
BIRC2 Rabbit Polyclonal Antibody
基因名称
BIRC2 API1 IAP2 MIHB RNF48
蛋白名称
Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13490
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13490/entry
Mouse Swissprot No.
Q62210
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62210
免疫原
Synthesized peptide derived from part region of human protein
特异性
BIRC2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
组织表达
Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
细胞定位
Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
信号通路
Ubiquitin mediated proteolysis;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Focal adhesion;NOD-like receptor;Pathways in cancer;Small cell lung cancer;
功能
function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
