产品名称
CO8G Rabbit Polyclonal Antibody
蛋白名称
Complement component C8 gamma chain
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P07360
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07360/entry
Mouse Swissprot No.
Q8VCG4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCG4
免疫原
Synthesized peptide derived from part region of human protein
特异性
CO8G Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011],
信号通路
Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;
功能
function:C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.,similarity:Belongs to the calycin superfamily. Lipocalin family.,subunit:C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
