BD-PN3005

I23O1 Rabbit Polyclonal Antibody

常规抗体

IDO1 IDO INDO

Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

3620

P14902

https://www.uniprot.org/uniprotkb/P14902/entry

P28776

http://www.uniprot.org/uniprot/P28776

Q9ERD9

http://www.uniprot.org/uniprot/O54941Q9ERD9

Synthesized peptide derived from part region of human protein

I23O1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

44kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011],

Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885).

Cytoplasm, cytosol .

Tryptophan metabolism;

cytokine production,?regulation of cytokine production,?negative regulation of cytokine production,?positive regulation of cytokine production,?response to molecule of bacterial origin,?acute inflammatory response,?production of molecular mediator of acute inflammatory response,?cytokine production during acute inflammatory response,?regulation of tolerance induction,?positive regulation of tolerance induction,?regulation of T cell tolerance induction,?positive regulation of T cell tolerance induction,?regulation of chronic inflammatory response,?positive regulation of chronic inflammatory response,?negative regulation of immune system process,?positive regulation of immune system process,regulation of leukocyte activation,?negative regulation of leukocyte activation,?regulation of adaptive immune response,?positive regulation of adaptive immune response,?regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains,?positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains,?regulation of T-helper 2 type immune response,?positive regulation of T-helper 2 type immune response,?tryptophan metabolic process,?tryptophan catabolic process,?cellular amino acid derivative metabolic process,?biogenic amine metabolic process,?indolalkylamine metabolic process,?coenzyme metabolic process,oxidoreduction coenzyme metabolic process,?nicotinamide metabolic process,?defense response,?inflammatory response,?female pregnancy,?behavior,?negative regulation of cell proliferation,?cellular amino acid catabolic process,aromatic amino acid family metabolic process,?aromatic amino acid family catabolic process,?amine catabolic process,response to wounding,?response to bacterium,?alkaloid metabolic process,?response to organic substance,?regulation of cell death,?organic acid biosynthetic process,?organic acid catabolic process,?heterocycle biosynthetic process,pyridine nucleotide metabolic process,?aromatic compound catabolic process,?tryptophan catabolic process to kynurenine,?NAD metabolic process,?secondary metabolic process,?positive regulation of defense response,?regulation of response to external stimulus,?positive regulation of response to external stimulus,?response to lipopolysaccharide,regulation of interleukin-10 production,?regulation of interleukin-12 production,?negative regulation of interleukin-10 production,?positive regulation of interleukin-12 production,?regulation of mononuclear cell proliferation,?negative regulation of mononuclear cell proliferation,?multicellular organismal response to stress,?kynurenic acid metabolic process,?kynurenic acid biosynthetic process,?regulation of cell proliferation,?regulation of T cell proliferation,?negative regulation of T cell proliferation,?cellular amino acid derivative catabolic process,?biogenic amine catabolic process,indole and derivative metabolic process,?indole derivative metabolic process,?indole derivative catabolic process,regulation of apoptosis,?negative regulation of apoptosis,?regulation of programmed cell death,?negative regulation of programmed cell death,?cellular amide metabolic process,?regulation of activated T cell proliferation,?negative regulation of activated T cell proliferation,?indolalkylamine catabolic process,?carboxylic acid biosynthetic process,carboxylic acid catabolic process,?nicotinamide nucleotide metabolic process,?heterocycle catabolic process,?positive regulation of response to stimulus,?regulation of lymphocyte proliferation,?negative regulation of lymphocyte proliferation,?regulation of inflammatory response,?positive regulation of inflammatory response,?positive regulation of immune response,?regulation of T cell activation,?regulation of cell activation,?negative regulation of cell activation,negative regulation of T cell activation,?cofactor metabolic process,?positive regulation of multicellular organismal process,?negative regulation of multicellular organismal process,?regulation of lymphocyte activation,?negative regulation of lymphocyte activation,?oxidation reduction,?negative regulation of cell death,?regulation of lymphocyte apoptosis,?negative regulation of lymphocyte apoptosis,?regulation of T cell apoptosis,?negative regulation of T cell apoptosis,?regulation of leukocyte proliferation,?negative regulation of leukocyte proliferation,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.