产品名称
MDHC Rabbit Polyclonal Antibody
蛋白名称
Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC 1.1.1.96)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P40925
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P40925/entry
Mouse Swissprot No.
P14152
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P14152
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O88989
免疫原
Synthesized peptide derived from part region of human protein
特异性
MDHC Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq,
组织表达
Brain,Cajal-Retzius cell,Heart,Placenta,T-cell,
信号通路
Citrate cycle (TCA cycle);Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;
功能
catalytic activity:(S)-malate + NAD(+) = oxaloacetate + NADH.,online information:Malate dehydrogenase entry,similarity:Belongs to the LDH/MDH superfamily. MDH type 2 family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.