产品名称
TAGL Rabbit Polyclonal Antibody
蛋白名称
Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q01995
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01995/entry
Mouse Swissprot No.
P37804
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P37804
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P31232
免疫原
Synthesized peptide derived from part region of human protein
特异性
TAGL Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Aorta,Bone marrow,Brain,Fibroblast,Human small intestine,Peripheral blood,Uterus,White Matt
功能
function:Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.,induction:Overexpressed in senescent human fibroblasts.,similarity:Belongs to the calponin family.,similarity:Contains 1 calponin-like repeat.,similarity:Contains 1 CH (calponin-homology) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
