产品名称
RFA4 Rabbit Polyclonal Antibody
蛋白名称
Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13156
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13156/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
RFA4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010],
组织表达
Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.
细胞定位
Nucleus . Localizes to DNA repair foci after DNA damage.
信号通路
DNA replication;Nucleotide excision repair;Mismatch repair;Homologous recombination;
功能
function:Absolutely required for simian virus 40 DNA replication in vitro. It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein.,subunit:Interacts with RPA1 and RPA3. In a tissue-specic manner, may replace RPA2 in the replication protein A heterotrimer.,tissue specificity:Preferentially expressed in placental and colon mucosa.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
