产品名称
RAMP1 Rabbit Polyclonal Antibody
蛋白名称
Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O60894
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60894/entry
Mouse Swissprot No.
Q9WTJ5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WTJ5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JJ74
免疫原
Synthesized peptide derived from part region of human protein
特异性
RAMP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided b
组织表达
Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Vascular smooth muscle contraction;
功能
function:Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.,similarity:Belongs to the RAMP family.,subunit:Heterodimer of CALCRL and RAMP1.,tissue specificity:Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
