产品名称
TAGL Rabbit Polyclonal Antibody
蛋白名称
Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q01995
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01995/entry
Mouse Swissprot No.
P37804
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P37804
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P31232
免疫原
Synthesized peptide derived from part region of human protein
特异性
TAGL Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Aorta,Bone marrow,Brain,Fibroblast,Human small intestine,Peripheral blood,Uterus,White Matt
功能
function:Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.,induction:Overexpressed in senescent human fibroblasts.,similarity:Belongs to the calponin family.,similarity:Contains 1 calponin-like repeat.,similarity:Contains 1 CH (calponin-homology) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
