BD-PN2957

GSHB Rabbit Polyclonal Antibody

常规抗体

GSS

Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

2937

P48637

https://www.uniprot.org/uniprotkb/P48637/entry

P51855

http://www.uniprot.org/uniprot/P51855

P46413

http://www.uniprot.org/uniprot/O54941P46413

Synthesized peptide derived from part region of human protein

GSHB Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

52kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008],

Brain,Fetal brain cortex,Kidney,Lung,

cytosol,extracellular exosome,

Glutathione metabolism;

catalytic activity:ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.,disease:Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency) [MIM:266130]; referred to as 5-oxoprolinuria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.,disease:Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes [MIM:231900]. It is a mild form causing hemolytic anemia.,pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.,similarity:Belongs to the eukaryotic GSH synthase family.,subunit:Homodimer.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.