产品名称
S29A2 Rabbit Polyclonal Antibody
基因名称
SLC29A2 DER12 ENT2 HNP36
蛋白名称
Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14542
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14542/entry
Mouse Swissprot No.
Q61672
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61672
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O54699
免疫原
Synthesized peptide derived from part region of human protein
特异性
S29A2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008],
组织表达
Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein . Nucleus membrane ; Multi-pass membrane protein . Localized at the basolateral cell membrane in polarized MDCK cells.
功能
function:Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.,induction:By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).,similarity:Belongs to the SLC29A transporter family.,tissue specificity:Expressed in placenta, brain, heart and ovarian tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
