产品名称
DSC3 Rabbit Polyclonal Antibody
蛋白名称
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14574
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14574/entry
Mouse Swissprot No.
P55850
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P55850
免疫原
Synthesized peptide derived from part region of human protein
特异性
DSC3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],
组织表达
Epidermis, buccal mucosa, esophagus and cervix.
细胞定位
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
功能
domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.,similarity:Contains 5 cadherin domains.,tissue specificity:Epidermis, buccal mucosa, esophagus and cervix.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
