产品名称
MARE3 Rabbit Polyclonal Antibody
蛋白名称
Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UPY8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UPY8/entry
Mouse Swissprot No.
Q6PER3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6PER3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5XIT1
免疫原
Synthesized peptide derived from part region of human protein
特异性
MARE3 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in brain and muscle.
细胞定位
Cytoplasm, cytoskeleton . Associated with the microtubule network. Detected at the plus end of microtubules. .
功能
domain:Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.,function:May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.,similarity:Belongs to the MAPRE family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 EB1 C-terminal domain.,subcellular location:Associated with the microtubule network.,subunit:Interacts with APC2 (By similarity). Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.,tissue specificity:Predominantly expressed in brain and muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
