产品名称
PRKRA Rabbit Polyclonal Antibody
基因名称
PRKRA PACT RAX HSD-14 HSD14
蛋白名称
Interferon-inducible double stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double stranded RNA-dependent activator)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75569
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75569/entry
Mouse Swissprot No.
Q9WTX2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WTX2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q4V8C7
免疫原
Synthesized peptide derived from part region of human protein
特异性
PRKRA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008],
组织表达
Brain,Epithelium,Placenta,Testis,
细胞定位
Cytoplasm, perinuclear region. Cytoplasm.
功能
disease:Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:612067]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.,function:Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor (By similarity). Activates EIF2AK2 in absence of double stranded RNA (dsRNA).,PTM:Phosphorylated on serine.,similarity:Contains 3 DRBM (double-stranded RNA-binding) domains.,subunit:Heterodimer. Interacts with EIF2AK2 through its DRBM domains. Also able to interact with dsRNA.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
