产品名称
TBX21 Rabbit Polyclonal Antibody
蛋白名称
T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UL17
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UL17/entry
Mouse Swissprot No.
Q9JKD8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JKD8
免疫原
Synthesized peptide derived from part region of human protein
特异性
TBX21 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
T-box 21(TBX21) Homo sapiens This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008],
功能
disease:Genetic variations in TBX21 are associated with susceptibility to aspirin-induced asthma [MIM:208550]. Asthma is defined as a chronic inflammatory lung disease that is characterized by airway hyperreactivity, eosinophil inflammation, and mucus hypersecretion resulting in intermittent airway obstruction.,disease:Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps [MIM:208550]. Nasal polyps is a chronic inflammatory disease of the paranasal sinus mucosa, leading to the protrusion of edematous polyps into the nasal cavities.,function:Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:T-cell specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
