产品名称
S5A1 Rabbit Polyclonal Antibody
蛋白名称
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.30) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P18405
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P18405/entry
Mouse Swissprot No.
Q68FF9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q68FF9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P24008
免疫原
Synthesized peptide derived from part region of human protein
特异性
S5A1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008],
组织表达
Liver and prostate (at a low level).
细胞定位
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .
信号通路
Steroid hormone biosynthesis;Androgen and estrogen metabolism;
功能
catalytic activity:A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.,function:Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.,induction:Its expression is regulated by androgens such as testosterone.,online information:5-alpha reductase entry,similarity:Belongs to the steroid 5-alpha reductase family.,tissue specificity:Liver and prostate (at a low level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
