产品名称
SFTA1 Rabbit Polyclonal Antibody
基因名称
SFTPA1 COLEC4 PSAP SFTP1 SFTPA SFTPA1B
蛋白名称
Pulmonary surfactant-associated protein A1 (PSP-A) (PSPA) (SP-A) (SP-A1) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IWL2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IWL2/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
SFTA1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
细胞定位
Secreted . Secreted, extracellular space, extracellular matrix . Secreted, extracellular space, surface film .
功能
disease:Genetic variations in SFTPA1 are associated with respiratory distress syndrome in premature infants (RDS) [MIM:267450]; also known as RDS in prematurity. RDS in the newborn is the main cause of mortality and morbidity in premature infants. RDS is characterized by deficient gas exchange that is caused by diffuse atelectasis and high-permeability lung edema that results in fibrin-rich alveolar deposits called 'hyaline membranes'. The risk of bronchopulmonary dysplasia increases with the severity of RDS.,function:In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.,miscellaneous:Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).,online information:Pulmonary surfactant protein SP-A1,polymorphism:A polymorphism in the SFTPA1 gene influences susceptibility to idiopathic pulmonary fibrosis [MIM:178500]. This polymorphism was associated with idiopathic pulmonary fibrosis in nonsmokers but not in smokers.,polymorphism:At least 5 allelic variants of SFTPA1 are known: 6A, 6A(2), 6A(3), 6A(4) and 6A(5). The sequence shown is that of allele 6A(3).,similarity:Belongs to the SFTPA family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 6 set of homotrimers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
