产品名称
MYCN Rabbit Polyclonal Antibody
蛋白名称
N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P04198
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P04198/entry
Mouse Swissprot No.
P03966
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P03966
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63379
免疫原
Synthesized peptide derived from part region of human protein
特异性
MYCN Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog(MYCN) Homo sapiens This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
组织表达
Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
功能
developmental stage:Expressed during fetal development.,disease:Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.,disease:Defects in MYCN are the cause of Feingold syndrome [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.,disease:Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence [MIM:602585].,function:May function as a transcription factor.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
