产品名称
NUCB1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4924
Human Swissprot No.
Q02818
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q02818/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18220
Mouse Swissprot No.
Q02819
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q02819
Rat Gene Link
https://www.uniprot.org/uniprot/84595
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63083
免疫原
Synthesized peptide derived from human NUCB1 AA range: 54-104
特异性
This antibody detects endogenous levels of NUCB1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010],
组织表达
Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.
细胞定位
Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein ; Lumenal side . Cytoplasm . Secreted . A small fraction of the protein may be cytoplasmic. .
功能
domain:The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition.,function:Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.,miscellaneous:Discovered as DNA-binding protein in the serum of lupus-prone mice.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the nucleobindin family.,similarity:Contains 2 EF-hand domains.,subcellular location:A small fraction of the protein may be cytoplasmic.,subunit:Interacts with GNAI2 and GNAI3.,tissue specificity:Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
