产品名称
GDF1 Rabbit Polyclonal Antibody
蛋白名称
Embryonic growth/differentiation factor 1 (GDF-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P27539
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P27539/entry
Mouse Swissprot No.
P20863
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P20863
免疫原
Synthesized peptide derived from part region of human protein AA range: 321-370
特异性
GDF1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016],
组织表达
Expressed in the brain.
功能
function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner.,function:May mediate cell differentiation events during embryonic development.,miscellaneous:This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.,miscellaneous:This protein is produced by a bicistronic gene which also produces the LASS1 protein from a non-overlapping reading frame.,similarity:Belongs to the TGF-beta family.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,subcellular location:Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in the brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
