产品名称
DVL1 Rabbit Polyclonal Antibody
蛋白名称
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O14640
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14640/entry
Mouse Swissprot No.
P51141
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51141
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9WVB9
免疫原
Synthesized peptide derived from part region of human protein
特异性
DVL1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008],
组织表达
Brain,Eye,Peripheral Nervous System,Sympathetic ganglion,Testis,
细胞定位
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members. .
信号通路
WNT;WNT-T CELLNotch;Melanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能
disease:May be partly responsible for CATCH22 syndromes. This denomination includes developmental defects which associate cardiac defect, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, and chromosome 22 deletions.,function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE.,tissue specificity:Expressed in the thymus and, at high levels, in the heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
