产品名称
PMVK Rabbit Polyclonal Antibody
蛋白名称
Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15126
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15126/entry
Mouse Swissprot No.
Q9D1G2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D1G2
免疫原
Synthesized peptide derived from part region of human protein
特异性
PMVK Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011],
组织表达
Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.
细胞定位
Cytoplasm, cytosol .
信号通路
Terpenoid backbone biosynthesis;
功能
catalytic activity:ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.,induction:By sterol.,pathway:Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via mevalonic acid pathway; isopentenyl-PP from (R)-mevalonic acid: step 2/3.,subunit:Monomer.,tissue specificity:Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta, and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
