产品名称
HMOX2 Rabbit Polyclonal Antibody
蛋白名称
Heme oxygenase 2 (HO-2) (EC 1.14.99.3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P30519
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30519/entry
Mouse Swissprot No.
O70252
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70252
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P23711
免疫原
Synthesized peptide derived from part region of human protein
特异性
HMOX2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
heme oxygenase 2(HMOX2) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013],
组织表达
Cerebellum,Intestine,Kidney,Lung,Placenta,
细胞定位
Microsome membrane ; Single-pass type IV membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .
信号通路
Porphyrin and chlorophyll metabolism;
功能
catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.,induction:Heme oxygenase 2 activity is non-inducible.,similarity:Belongs to the heme oxygenase family.,similarity:Contains 2 HRM (heme regulatory motif) repeats.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
