产品名称
TBB4A Rabbit Polyclonal Antibody
蛋白名称
Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P04350
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P04350/entry
Mouse Swissprot No.
Q9D6F9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D6F9
免疫原
Synthesized peptide derived from part region of human protein AA range: 218-268
特异性
TBB4A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014],
组织表达
Major isotype in brain, where it represents 46% of all beta-tubulins. In the brain, highest expression levels in the cerebellum, followed by putamen and white matter. Moderate levels in testis. Very low levels, if any, in other tissues.
细胞定位
Cytoplasm, cytoskeleton.
信号通路
Gap junction;Pathogenic Escherichia coli infection;
功能
domain:The highly acidic C-terminal region may bind cations such as calcium.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
