产品名称
ABI3 Rabbit Polyclonal Antibody
蛋白名称
ABI gene family member 3 (New molecule including SH3) (Nesh)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9P2A4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P2A4/entry
Mouse Swissprot No.
Q8BYZ1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BYZ1
免疫原
Synthesized peptide derived from part region of human protein AA range: 286-336
特异性
ABI3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
组织表达
Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
细胞定位
Cytoplasm . Colocalizes with PAK2 at leading edge of cells.
功能
function:May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.,similarity:Belongs to the ABI family.,similarity:Contains 1 SH3 domain.,subcellular location:Colocalizes with PAK2 at leading edge of cells.,subunit:May interact with PAK1 and PAK2. Probably interacts with TARSH.,tissue specificity:Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
