产品名称
PROF2 Rabbit Polyclonal Antibody
蛋白名称
Profilin-2 (Profilin II)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P35080
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P35080/entry
Mouse Swissprot No.
Q9JJV2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JJV2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9EPC6
免疫原
Synthesized peptide derived from part region of human protein
特异性
PROF2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
细胞定位
Cytoplasm, cytoskeleton.
信号通路
Regulates Actin and Cytoskeleton;
功能
function:Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.,similarity:Belongs to the profilin family.,subunit:Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.,tissue specificity:Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
