产品名称
PROF1 Rabbit Polyclonal Antibody
蛋白名称
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P07737
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07737/entry
Mouse Swissprot No.
P62962
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62962
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P62963
免疫原
Synthesized peptide derived from part region of human protein
特异性
PROF1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012],
组织表达
Expressed in epididymis (at protein level).
细胞定位
Cytoplasm, cytoskeleton.
信号通路
Regulates Actin and Cytoskeleton;
功能
function:Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.,similarity:Belongs to the profilin family.,subunit:Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
