产品名称
RBP10 Rabbit Polyclonal Antibody
蛋白名称
Ran-binding protein 10 (RanBP10)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6VN20
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6VN20/entry
Mouse Swissprot No.
Q6VN19
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6VN19
免疫原
Synthesized peptide derived from part region of human protein AA range: 353-403
特异性
RBP10 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
RAN binding protein 10(RANBP10) Homo sapiens RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],
组织表达
Broadly expressed, with highest levels in skeletal muscle.
细胞定位
Cytoplasm, cytosol . Nucleus . Predominantly cytoplasmic.
功能
domain:The SPRY domain mediates the interaction with MET.,function:May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.,similarity:Belongs to the RANBP9/10 family.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 CTLH domain.,similarity:Contains 1 LisH domain.,subunit:Interacts with RAN. Interacts with the HGF receptor MET.,tissue specificity:Broadly expressed, with highest levels in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
