产品名称
BRD2 Rabbit Polyclonal Antibody
蛋白名称
Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P25440
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P25440/entry
Mouse Swissprot No.
Q7JJ13
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7JJ13
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6MGA9
免疫原
Synthesized peptide derived from part region of human protein AA range: 300-350
特异性
BRD2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010],
组织表达
Bone marrow,Epithelium,PNS,T-cell,Testis,
细胞定位
Nucleus . Detected on chromatin and nucleosomes.
功能
domain:One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'.,function:May play a role in spermatogenesis or folliculogenesis.,similarity:Contains 1 ET domain.,similarity:Contains 2 bromo domains.,subunit:Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
