产品名称
STAM1 Rabbit Polyclonal Antibody
蛋白名称
Signal transducing adapter molecule 1 (STAM-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92783
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92783/entry
Mouse Swissprot No.
P70297
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70297
免疫原
Synthesized peptide derived from part region of human protein AA range: 156-206
特异性
STAM1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011],
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
信号通路
Endocytosis;Jak_STAT;
功能
function:Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.,PTM:Phosphorylated on Tyr-198. Phosphorylation occurs in response to IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF.,similarity:Belongs to the STAM family.,similarity:Contains 1 ITAM domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,similarity:Contains 1 VHS domain.,subunit:Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
