产品名称
DNMBP Rabbit Polyclonal Antibody
蛋白名称
Dynamin-binding protein (Scaffold protein Tuba)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6XZF7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6XZF7/entry
Mouse Swissprot No.
Q6TXD4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6TXD4
免疫原
Synthesized peptide derived from part region of human protein AA range: 940-990
特异性
DNMBP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
组织表达
Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.
细胞定位
Cytoplasm . Golgi apparatus, Golgi stack . Cytoplasm, cytoskeleton . Cell junction, synapse . Cell junction . Localizes to the apical junction, colocalizes with TJP1. .
功能
function:Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi.,similarity:Contains 1 BAR domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 6 SH3 domains.,subcellular location:Localized to synapses and Golgi stacks.,subunit:Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1.,tissue specificity:Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
