产品名称
URP2 Rabbit Polyclonal Antibody
基因名称
FERMT3 KIND3 MIG2B URP2
蛋白名称
Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q86UX7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86UX7/entry
Mouse Swissprot No.
Q8K1B8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K1B8
免疫原
Synthesized peptide derived from part region of human protein AA range: 52-102
特异性
URP2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010],
组织表达
Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
细胞定位
Cell projection, podosome . Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. .
功能
domain:The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.,function:Probably involved in cell adhesion.,similarity:Belongs to the kindlin family.,similarity:Contains 1 FERM domain.,similarity:Contains 1 PH domain.,subcellular location:Membrane-associated in chronic lymphocytic leukemia (CLL) cells.,tissue specificity:Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
