产品名称
KIRR1 Rabbit Polyclonal Antibody
基因名称
KIRREL KIRREL1 NEPH1
蛋白名称
Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96J84
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96J84/entry
Mouse Swissprot No.
Q80W68
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80W68
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6X936
免疫原
Synthesized peptide derived from part region of human protein AA range: 166-216
特异性
KIRR1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008],
组织表达
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Predominantly located at podocyte slit diaphragm.
功能
function:Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.,PTM:Phosphorylation probably regulates the interaction with NSH2.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Predominantly located at podocyte slit diaphragm.,subunit:Interacts with NPHS1/nephrin, TJP1/ZO-1 and C-terminus of NPHS2/podocin.,tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
