产品名称
CLH1 Rabbit Polyclonal Antibody
基因名称
CLTC CLH17 CLTCL2 KIAA0034
蛋白名称
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q00610
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q00610/entry
免疫原
Synthesized peptide derived from part region of human protein AA range: 482-532
特异性
CLH1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008],
组织表达
Bone marrow,Brain,Cervix carcinoma,Colon,Epithelium,Fetal kidney,Hepatoma,Mammary c
细胞定位
Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side . Melanosome . Cytoplasm, cytoskeleton, spindle . Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. .
信号通路
Lysosome;Endocytosis;Huntington's disease;
功能
function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.,online information:Clathrin entry,similarity:Belongs to the clathrin heavy chain family.,subcellular location:Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
