产品名称
NUDT5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11164
Human Swissprot No.
Q9UKK9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKK9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/53893
Mouse Swissprot No.
Q9JKX6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JKX6
Rat Gene Link
https://www.uniprot.org/uniprot/361274
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AY63
免疫原
Synthesized peptide derived from human NUDT5 AA range: 95-145
特异性
This antibody detects endogenous levels of NUDT5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013],
组织表达
Widely expressed. Most abundant in liver.
功能
catalytic activity:ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate.,catalytic activity:ADP-sugar + H(2)O = AMP + alpha-D-aldose 5-phosphate.,cofactor:Magnesium.,function:Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity.,similarity:Belongs to the Nudix hydrolase family.,subunit:Homodimer.,tissue specificity:Widely expressed. Most abundant in liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
