产品名称
MC3R Rabbit Polyclonal Antibody
蛋白名称
Melanocortin receptor 3 (MC3-R)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P41968
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P41968/entry
Mouse Swissprot No.
P33033
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P33033
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P32244
免疫原
Synthesized peptide derived from human protein . at AA range: 280-360
特异性
MC3R Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008],
组织表达
Brain, placental, and gut tissues.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.,polymorphism:Genetic variations in MC3R define the body mass index quantitative trait locus 9 (BMIQ9) [MIM:602025]. Variance in body mass index is a susceptibility factor for obesity.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Brain, placental, and gut tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
