产品名称
PBIP1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57326
Human Swissprot No.
Q96AQ6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96AQ6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/229534
Mouse Swissprot No.
Q3TVI8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TVI8
Rat Gene Link
https://www.uniprot.org/uniprot/310644
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/A2VD12
免疫原
Synthesized peptide derived from human PBIP1 AA range: 585-635
特异性
This antibody detects endogenous levels of PBIP1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015],
组织表达
Expressed in early hematopoietic precursors.
细胞定位
Cytoplasm, cytoskeleton . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
功能
domain:Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).,domain:The C-terminal domain (AA 443-731) contains a nuclear export signal.,function:Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.,subcellular location:Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.,subunit:Interacts with ESR1, PBX1, PBX2 and PBX3.,tissue specificity:Expressed in early hematopietic precursors.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
