产品名称
TA2R4 Rabbit Polyclonal Antibody
蛋白名称
Taste receptor type 2 member 4 (T2R4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NYW5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NYW5/entry
Mouse Swissprot No.
Q9JKT3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JKT3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q67ET0
免疫原
Synthesized peptide derived from human protein . at AA range: 10-90
特异性
TA2R4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008],
组织表达
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.
细胞定位
Membrane ; Multi-pass membrane protein . Cell projection, cilium membrane . In airway epithelial cells, localizes to motile cilia.
功能
function:Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.,miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
