产品名称
TA2R Rabbit Polyclonal Antibody
蛋白名称
Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P21731
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P21731/entry
Mouse Swissprot No.
P30987
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30987
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P34978
免疫原
Synthesized peptide derived from human protein . at AA range: 230-310
特异性
TA2R Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
thromboxane A2 receptor(TBXA2R) Homo sapiens This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
组织表达
Blood,Endothelial cell,Lung,PCR rescued clones,Placenta,Platelet,
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;
功能
disease:Defects in TBXA2R are the cause of a dominantly inherited bleeding disorder [MIM:188070].,function:Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase, isoform 2 inhibits adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
