产品名称
PTH2R Rabbit Polyclonal Antibody
蛋白名称
Parathyroid hormone 2 receptor (PTH2 receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49190
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49190/entry
Mouse Swissprot No.
Q91V95
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91V95
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P70555
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
PTH2R Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
组织表达
Expressed abundantly in brain and pancreas. Also expressed in the testis.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.,similarity:Belongs to the G-protein coupled receptor 2 family.,subunit:Binds to TIPF39/TIP39.,tissue specificity:Expressed abundantly in brain and pancreas. Also expressed in the testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
