产品名称
PACR Rabbit Polyclonal Antibody
蛋白名称
Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P41586
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P41586/entry
Mouse Swissprot No.
P70205
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70205
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P32215
免疫原
Synthesized peptide derived from human protein . at AA range: 80-160
特异性
PACR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010],
组织表达
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
