产品名称
P2Y12 Rabbit Polyclonal Antibody
蛋白名称
P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H244
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H244/entry
Mouse Swissprot No.
Q9CPV9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CPV9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9EPX4
免疫原
Synthesized peptide derived from human protein . at AA range: 110-190
特异性
P2Y12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
组织表达
Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
disease:Defects in P2RY12 are a cause of bleeding disorder [MIM:609821].,function:Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
