产品名称
P2RY2 Rabbit Polyclonal Antibody
蛋白名称
P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (Purinergic receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P41231
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P41231/entry
Mouse Swissprot No.
P35383
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P35383
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P41232
免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
P2RY2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
purinergic receptor P2Y2(P2RY2) Homo sapiens The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013],
组织表达
Spleen, testis, kidney, liver, lung, heart and brain.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Spleen, testis, kidney, liver, lung, heart and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
