产品名称
P2RY1 Rabbit Polyclonal Antibody
蛋白名称
P2Y purinoceptor 1 (P2Y1) (ATP receptor) (Purinergic receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P47900
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P47900/entry
Mouse Swissprot No.
P49650
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P49650
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P49651
免疫原
Synthesized peptide derived from human protein . at AA range: 130-210
特异性
P2RY1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
purinergic receptor P2Y1(P2RY1) Homo sapiens The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008],
组织表达
Blood,Brain,Lung,Placenta,Platelet,
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.,induction:Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
