产品名称
OPSB Rabbit Polyclonal Antibody
蛋白名称
Short-wave-sensitive opsin 1 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P03999
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P03999/entry
Mouse Swissprot No.
P51491
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51491
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63652
免疫原
Synthesized peptide derived from part region of human protein
特异性
OPSB Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008],
组织表达
The three color pigments are found in the cone photoreceptor cells (PubMed:2937147). Expressed throughout the epidermis and dermis, primarily in the stratum granulosum in the facial and abdominal skin (at protein level) (PubMed:30168605). Expressed in dermal fibroblasts (at protein level) (PubMed:31380578). Expressed in melanocytes (at protein level) (PubMed:31730232).
细胞定位
Cell membrane ; Multi-pass membrane protein . Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Cytoplasm, perinuclear region .
功能
disease:Defects in OPN1SW are the cause of tritan color blindness (tritanopia) [MIM:190900].,function:Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.,online information:Retina International's Scientific Newsletter,PTM:Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.,tissue specificity:The three color pigments are found in the cone photoreceptor cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
